Longitudinal change of biomarkers in cognitive decline.

ABSTRACT:

Objective

To delineate the trajectories of Aβ42 level in cerebrospinal fluid (CSF), fludeoxyglucose F18 (FDG) uptake using positron emission tomography, and hippocampal volume using magnetic resonance imaging and their relative associations with cognitive change at different stages in aging and Alzheimer disease (AD).

Design

Cohort study.

Setting

The 59 study sites for the Alzheimer's Disease Neuroimaging Initiative.

Participants

A total of 819 participants 55 to 90 years of age with normal cognition, mild cognitive impairment, and AD who were followed up during the period from 2005 to 2007.

Main outcome measures

Rates of change in level of Aβ42 in CSF, FDG uptake, hippocampal volume, and the Alzheimer Disease's Assessment Scale-cognitive subscale score

SUBMITTER: Lo RY 

PROVIDER: S-EPMC5604752 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature