Chimeric antigen receptor-engineered natural killer and natural killer T cells for cancer immunotherapy.

ABSTRACT: Natural killer (NK) cells of the innate immune system and natural killer T (NKT) cells, which have roles in both the innate and adaptive responses, are unique lymphocyte subsets that have similarities in their functions and phenotypes. Both cell types can rapidly respond to the presence of tumor cells and participate in immune surveillance and antitumor immune responses. This has incited interest in the development of novel cancer therapeutics based on NK and NKT cell manipulation. Chimeric antigen receptors (CARs), generated through the fusion of an antigen-binding region of a monoclonal antibody or other ligand to intracellular signaling domains, can enhance lymphocyte targeting and activation toward diverse malignancies. Most of the CAR studies have focused on their expression in T cell

SUBMITTER: Bollino D 

PROVIDER: S-EPMC5604792 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature