Controlling the Biomimetic Implant Interface: Modulating Antimicrobial Activity by Spacer Design.

ABSTRACT: Surgical site infection is a common cause of post-operative morbidity, often leading to implant loosening, ultimately requiring revision surgery, increased costs and worse surgical outcomes. Since implant failure starts at the implant surface, creating and controlling the bio-material interface will play a critical role in reducing infection while improving host cell-to-implant interaction. Here, we engineered a biomimetic interface based upon a chimeric peptide that incorporates a titanium binding peptide (TiBP) with an antimicrobial peptide (AMP) into a single molecule to direct binding to the implant surface and deliver an antimicrobial activity against S. mutans and S. epidermidis, two bacteria which are linked with clinical implant infections. To optimize antimicrobial a

SUBMITTER: Wisdom C 

PROVIDER: S-EPMC5604879 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature