SOX14 activates the p53 signaling pathway and induces apoptosis in a cervical carcinoma cell line.

ABSTRACT: SOX14 is a member of the SOX family of transcription factors mainly involved in the regulation of neural development. Recently, it became evident that SOX14 is one of four hypermethylated genes in cervical carcinoma, considered as a tumor suppressor candidate in this type of malignancy. In this paper we elucidated the role of SOX14 in the regulation of malignant properties of cervical carcinoma cells in vitro. Functional analysis performed in HeLa cells revealed that SOX14 overexpression decreased viability and promoted apoptosis through altering the expression of apoptosis related genes. Our results demonstrated that overexpression of SOX14 initiated accumulation of p53, demonstrating potential cross-talk between SOX14 and the p53 signaling pathway. Further analysis unambiguously showed t

SUBMITTER: Stanisavljevic D 

PROVIDER: S-EPMC5604970 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature