Meta-analysis of promoter methylation in eight tumor-suppressor genes and its association with the risk of thyroid cancer.

ABSTRACT: Promoter methylation in a number of tumor-suppressor genes (TSGs) can play crucial roles in the development of thyroid carcinogenesis. The focus of the current meta-analysis was to determine the impact of promoter methylation of eight selected candidate TSGs on thyroid cancer and to identify the most important molecules in this carcinogenesis pathway. A comprehensive search was performed using Pub Med, Scopus, and ISI Web of Knowledge databases, and eligible studies were included. The methodological quality of the included studies was evaluated according to the Newcastle Ottawa scale table and pooled odds ratios (ORs); 95% confidence intervals (CIs) were used to estimate the strength of the associations with Stata 12.0 software. Egger's and Begg's tests were applied to detect publication b

SUBMITTER: Khatami F 

PROVIDER: S-EPMC5605048 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature