Effect of accurate heart delineation on cardiac dose during the CONVERT trial.

ABSTRACT:

Objective

This study investigated the effect of deviation from protocol in heart delineation for the Concurrent Once-daily Versus twice-daily Radiotherapy (CONVERT) Trial ( ClinicalTrials.gov Identifier NCT00433563) quality assurance (QA) programme and the effect of that on mean cardiac dose and percentage of heart volume receiving ≥5 Gy (V_5%) and percentage of heart volume receiving ≥30 Gy (V_30%).

Methods

Patients with limited-stage small-cell lung cancer in the CONVERT trial were randomized to receive 45 Gy in 30# twice daily or 66 Gy in 33# once daily radiotherapy, with concurrent chemotherapy in both arms. Of the 100 trial patient cases reviewed by the QA team [for patient selection, disease/organs at risk (OARs) outlining and treatment planning], 5

SUBMITTER: Groom N 

PROVIDER: S-EPMC5605115 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature