Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy.

ABSTRACT:

Background

Subclinical thyroid disease during pregnancy may be associated with adverse outcomes, including a lower-than-normal IQ in offspring. It is unknown whether levothyroxine treatment of women who are identified as having subclinical hypothyroidism or hypothyroxinemia during pregnancy improves cognitive function in their children.

Methods

We screened women with a singleton pregnancy before 20 weeks of gestation for subclinical hypothyroidism, defined as a thyrotropin level of 4.00 mU or more per liter and a normal free thyroxine (T₄) level (0.86 to 1.90 ng per deciliter [11 to 24 pmol per liter]), and for hypothyroxinemia, defined as a normal thyrotropin level (0.08 to 3.99 mU per liter) and a low free T₄ level (<0.86 ng per deciliter). In separat

SUBMITTER: Casey BM 

PROVIDER: S-EPMC5605129 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature