Towards precision medicine in Alzheimer's disease: deciphering genetic data to establish informative biomarkers.

ABSTRACT:

Introduction

Developing biomarker tools for identification of individuals at high-risk for late-onset Alzheimer's disease (LOAD) is important for prognosis and early treatment. This review focuses on genetic factors and their potential role for precision medicine in LOAD.

Areas covered

APOEe4 is the strongest genetic risk factor for non-Mendelian LOAD, and the APOE-linkage disequilibrium (LD) region has produced the most significant association signal in multi-center genome-wide-association-studies (GWAS). Consideration of extended haplotypes in the APOE-LD region and specifically, non-coding variants in putative enhancer elements, such as the TOMM40-polyT, in-addition to the coding variants that comprise the APOE-genotypes, may be useful f

SUBMITTER: Chiba-Falek O 

PROVIDER: S-EPMC5605187 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature