Dataset Information
Quantitative FLAIR MRI in Amyotrophic Lateral Sclerosis.
Ontology highlight
ABSTRACT: Rationale and objectives
T2-weighted magnetic resonance imaging (MRI) hyperintensity assessed visually in the corticospinal tract (CST) lacks sensitivity for a diagnosis of amyotrophic lateral sclerosis (ALS). We sought to explore a quantitative approach to fluid-attenuated inversion recovery (FLAIR) MRI intensity across a range of ALS phenotypes.Materials and methods
Thirty-three classical ALS patients, 10 with a flail arm presentation, and six with primary lateral sclerosis underwent MRI at 3 Tesla. Comparisons of quantitative FLAIR intensity in the CST and corpus callosum were made between 21 healthy controls and within patient phenotypic subgroups, some of whom were studied longitudinally.Results
Mean FLAIR intensity was greater in patient groups. The cerebral peduncle intensity provided the strongest subgroup classification. FLAIR intensity increased longitudinally. The rate of change of FLAIR within CST correlated with rate of decline in executive function and ALS functional rating score.Conclusions
FLAIR MRI encodes quantifiable information of potential diagnostic, stratification, and monitoring value.
SUBMITTER: Fabes J
PROVIDER: S-EPMC5605225 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Quantitative FLAIR MRI in Amyotrophic Lateral Sclerosis.
Academic radiology 20170529 10
<h4>Rationale and objectives</h4>T2-weighted magnetic resonance imaging (MRI) hyperintensity assessed visually in the corticospinal tract (CST) lacks sensitivity for a diagnosis of amyotrophic lateral sclerosis (ALS). We sought to explore a quantitative approach to fluid-attenuated inversion recovery (FLAIR) MRI intensity across a range of ALS phenotypes.<h4>Materials and methods</h4>Thirty-three classical ALS patients, 10 with a flail arm presentation, and six with primary lateral sclerosis und ...[more]
