Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis.

ABSTRACT: Most individuals at ultra-high risk (UHR) for psychosis do not transition to frank illness. Nevertheless, many have poor clinical outcomes and impaired psychosocial functioning. This study used voxel-based morphometry to investigate if baseline grey and white matter brain densities at identification as UHR were associated with functional outcome at medium- to long-term follow-up. Participants were help-seeking UHR individuals (n = 109, 54M:55F) who underwent magnetic resonance imaging at baseline; functional outcome was assessed an average of 9.2 years later. Primary analysis showed that lower baseline grey matter density, but not white matter density, in bilateral frontal and limbic areas, and left cerebellar declive were associated with poorer functional outcome (Social and Occupational

SUBMITTER: Reniers RL 

PROVIDER: S-EPMC5605267 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature