Brain-Wide Analysis of Functional Connectivity in First-Episode and Chronic Stages of Schizophrenia.

ABSTRACT: Published reports of functional abnormalities in schizophrenia remain divergent due to lack of staging point-of-view and whole-brain analysis. To identify key functional-connectivity differences of first-episode (FE) and chronic patients from controls using resting-state functional MRI, and determine changes that are specifically associated with disease onset, a clinical staging model is adopted. We analyze functional-connectivity differences in prodromal, FE (mostly drug naïve), and chronic patients from their matched controls from 6 independent datasets involving a total of 789 participants (343 patients). Brain-wide functional-connectivity analysis was performed in different datasets and the results from the datasets of the same stage were then integrated by meta-analysis, with Bonferro

SUBMITTER: Li T 

PROVIDER: S-EPMC5605268 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature