Estimating prognosis at the time of repeat whole brain radiation therapy for multiple brain metastases: The reirradiation score.

ABSTRACT:

Purpose

Whole brain radiation therapy (WBRT) remains the standard of care for patients with multiple brain metastases, but more than half of treated patients will develop intracranial progression. Because there is no clear consensus on the optimal therapeutic approach, a prognostic index would be helpful to guide treatment options at progression. We explored whether the recursive partitioning analysis (RPA) score prior to repeat WBRT is predictive of survival.

Methods and materials

This multi-institutional pooled analysis included patients with 2 or more brain metastases from any solid primary tumor that was treated with 2 courses of WBRT. Information on demographics, disease characteristics, and intervals between courses was collected. RPA class was abstracted or retrospect

SUBMITTER: Logie N 

PROVIDER: S-EPMC5605302 | biostudies-literature | 2017 Jul-Sep

REPOSITORIES: biostudies-literature