Long-term economic value of hypofractionated prostate radiation: Secondary analysis of a randomized trial.

ABSTRACT:

Purpose

Moderately hypofractionated intensity modulated radiation therapy (HIMRT) for prostate cancer shortens the treatment course while providing outcomes comparable with those of conventional intensity modulated radiation therapy (CIMRT). To determine the long-term economic value of HIMRT, including the costs of managing long-term radiation toxicities, a cost minimization analysis compared CIMRT with dose-escalated HIMRT using patient-level data from a randomized trial.

Methods and materials

Men with localized prostate cancer were randomized to CIMRT (75.6 Gy in 42 fractions over 8.4 weeks) or HIMRT (72 Gy in 30 fractions over 6 weeks). A decision tree modeled trial probabilities of maximum late bowel and urinary toxicities using patient-level data with a median follow-up

SUBMITTER: Voong KR 

PROVIDER: S-EPMC5605303 | biostudies-literature | 2017 Jul-Sep

REPOSITORIES: biostudies-literature