Mesothelin-specific Immune Responses Predict Survival of Patients With Brain Metastasis.

ABSTRACT:

Background

Patients with advanced malignancies, e.g. lung cancer, ovarian cancer or melanoma, frequently present with brain metastases. Clinical presentation and disease progression of cancer is in part shaped by the interaction of the immune system with malignant cells. Antigen-targeted immune responses have been implicated in the prolonged survival of patients with cancer. This includes the tumor-associated antigen (TAA) mature mesothelin, a 40kDa cell surface-bound antigen that is overexpressed in several malignancies including lung ovarian and pancreatic cancer. We examined in an observational, prospective study the survival of patients with brain metastases in association with clinical parameters and cellular immune responses to molecularly defined TAAs or viral (control) targ

SUBMITTER: Zhenjiang L 

PROVIDER: S-EPMC5605370 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature