Protracted and asynchronous accumulation of PSD95-family MAGUKs during maturation of nascent dendritic spines.

ABSTRACT: The formation and stabilization of new dendritic spines is a key component of the experience-dependent neural circuit plasticity that supports learning, but the molecular maturation of nascent spines remains largely unexplored. The PSD95-family of membrane-associated guanylate kinases (PSD-MAGUKs), most notably PSD95, has a demonstrated role in promoting spine stability. However, nascent spines contain low levels of PSD95, suggesting that other members of the PSD-MAGUK family might act to stabilize nascent spines in the early stages of spiny synapse formation. Here, we used GFP-fusion constructs to quantitatively define the molecular composition of new spines, focusing on the PSD-MAGUK family. We found that PSD95 levels in new spines were as low as those previously associated with rapid su

SUBMITTER: Lambert JT 

PROVIDER: S-EPMC5605399 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature