Diffusion-relaxation correlation spectroscopic imaging: A multidimensional approach for probing microstructure.

ABSTRACT:

Purpose

To propose and evaluate a novel multidimensional approach for imaging subvoxel tissue compartments called Diffusion-Relaxation Correlation Spectroscopic Imaging.

Theory and methods

Multiexponential modeling of MR diffusion or relaxation data is commonly used to infer the many different microscopic tissue compartments that contribute signal to macroscopic MR imaging voxels. However, multiexponential estimation is known to be difficult and ill-posed. Observing that this ill-posedness is theoretically reduced in higher dimensions, diffusion-relaxation correlation spectroscopic imaging uses a novel multidimensional imaging experiment that jointly encodes diffusion and relaxation information, and then uses a novel constrained reconstruction technique to generate a multidi

SUBMITTER: Kim D 

PROVIDER: S-EPMC5605406 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature