Crosstalk between type II NKT cells and T cells leads to spontaneous chronic inflammatory liver disease.

ABSTRACT:

Background & aim

Natural killer T (NKT) cells are CD1d-restricted innate-like T cells that modulate innate and adaptive immune responses. Unlike the well-characterized invariant/type I NKT cells, type II NKT cells with a diverse T cell receptor repertoire are poorly understood. This study defines the pathogenic role of type II NKT cells in the etiology of chronic liver inflammation.

Methods

Transgenic mice with the Lck promoter directing CD1d overexpression on T cells in Jα18 wild-type (Lck-CD1dTgJα18⁺; type I NKT cell sufficient) and Jα18-deficient (Lck-CD1dTgJα18^o, type I NKT cell deficient) mice were analyzed for liver pathology and crosstalk between type II NKT cells and conventional T cells. CD1d expression on T cells in peripheral blood samples an

SUBMITTER: Weng X 

PROVIDER: S-EPMC5605413 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature