Optimal MRI sequences for ⁶⁸Ga-PSMA-11 PET/MRI in evaluation of biochemically recurrent prostate cancer.

ABSTRACT:

Background

PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with ⁶⁸Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on ⁶⁸Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prostate cancer patients with BCR imaged with ⁶⁸Ga-PSMA-11 3.0T PET/MRI were retrospectively analyzed. Mean PSA was 7.9 ± 12.9 ng/ml, and mean PSA doubling time was 7.1 ± 6.6 months. Detection rates of anatomic correlates for prostate-specific membrane antigen (PSMA)-positive foci were evaluated on small field of view (FOV) T2, T1 post-contrast, and diffusion-weighted images. For prostate bed recurrences, the detection rate of dynamic contra

SUBMITTER: Lake ST 

PROVIDER: S-EPMC5605480 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature