Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells.

ABSTRACT: Group3 medulloblastoma (MB_G3) that predominantly occur in young children are usually associated with MYC amplification and/or overexpression, frequent metastasis and a dismal prognosis. Physiologically relevant MB_G3 models are currently lacking, making inferences related to their cellular origin thus far limited. Using in utero electroporation, we here report that MB_G3 mouse models can be developed in situ from different multipotent embryonic cerebellar progenitor cells via conditional expression of Myc and loss of Trp53 function in several Cre driver mouse lines. The Blbp-Cre driver that targets embryonic neural progenitors induced tumors exhibiting a large-cell/anaplastic histopathology adjacent to the fourth ventricle, recapitulating human MB_G3

SUBMITTER: Kawauchi D 

PROVIDER: S-EPMC5605674 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature