Urinary Exosomal MicroRNA Profiling in Incipient Type 2 Diabetic Kidney Disease.

ABSTRACT:

Background

Albuminuria is an early sign but not a strong predictor of diabetic kidney disease (DKD). Owing to their high stability, urinary exosomal miRNAs can be useful predictors of the progression of early-stage DKD to renal failure; fluid biopsies are ideal for detecting abnormalities in these miRNAs. The aim of this study was to identify novel differentially expressed miRNAs as urine biomarkers for type 2 DKD by comparing between patients of type 2 diabetes (T2D) with and without macroalbuminuria.

Methods

Ten patients with T2D, including five who had no renal disease and five with macroalbuminuria (DKD G1-2A3), were selected for this study. Exosome- (UExo-) derived miRNA profiles were used to identify candidate biomarkers, a subset of which was verified using quantitati

SUBMITTER: Xie Y 

PROVIDER: S-EPMC5605810 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature