Overexpression of the Cytokine BAFF and Autoimmunity Risk.

ABSTRACT:

Background

Genomewide association studies of autoimmune diseases have mapped hundreds of susceptibility regions in the genome. However, only for a few association signals has the causal gene been identified, and for even fewer have the causal variant and underlying mechanism been defined. Coincident associations of DNA variants affecting both the risk of autoimmune disease and quantitative immune variables provide an informative route to explore disease mechanisms and drug-targetable pathways.

Methods

Using case-control samples from Sardinia, Italy, we performed a genomewide association study in multiple sclerosis followed by TNFSF13B locus-specific association testing in systemic lupus erythematosus (SLE). Extensive phenotyping of quantitative immune variables, sequence-bas

SUBMITTER: Steri M 

PROVIDER: S-EPMC5605835 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature