BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation.

ABSTRACT: The bacterial second messenger cyclic dimeric GMP (c-di-GMP) is a nearly ubiquitous intracellular signaling molecule involved in the transition from the motile to the sessile/biofilm state in bacteria. C-di-GMP regulates various cellular processes, including biofilm formation, motility, and virulence. BolA is a transcription factor that promotes survival in different stresses and is also involved in biofilm formation. Both BolA and c-di-GMP participate in the regulation of motility mechanisms leading to similar phenotypes. Here, we establish the importance of the balance between these two factors for accurate regulation of the transition between the planktonic and sessile lifestyles. This balance is achieved by negative-feedback regulation of BolA and c-di-GMP. BolA not only contributes di

SUBMITTER: Moreira RN 

PROVIDER: S-EPMC5605933 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature