Tumor-related interleukins: old validated targets for new anti-cancer drug development.

ABSTRACT: In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong regulation of cancer development and progression by the inflammation which orchestrates the tumor microenvironment. Immune cells, residents or recruited, in the inflammation milieu can have rather contrasting effects during cancer development. Accumulated clinical and experimental data support the notion that acute inflammation could exert an immunoprotective effect leading to tumor eradication. However, chronic immune response promotes tumor growth and invasion. These reactions are mediated by soluble mediators or cytokines produced by either host immune cells or tumor cells themselves. Herein, we provide an overview of the current understanding of the role of the best-validated cytokines involved in tum

SUBMITTER: Setrerrahmane S 

PROVIDER: S-EPMC5606116 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature