Fasciclin-calcareous corpuscle binary complex mediated protein-protein interactions in Taenia solium metacestode.

ABSTRACT:

Background

Neurocysticercosis (NC) caused by Taenia solium metacestode (TsM) is a serious neurological disease of global concern. Diverse bioactive molecules involved in the long-term survival of TsM might contribute to disease progression. Fasciclin (Fas) is an extracellular protein that mediates adhesion, migration and differentiation of cells by interacting with other molecules. We hypothesized that TsMFas might bind to calcareous corpuscle (CC) through its adhesive property and participate in crucial protein-protein interactions, thus contributing to the creation of a symbiotic interactome network.

Methods

Two paralogous TsMFas (TsMFas1 and TsMFas2) were isolated, and their molecular properties were characterized. The co-localization pattern of TsMFas1 and TsMFas2 with C

SUBMITTER: Ahn CS 

PROVIDER: S-EPMC5606126 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature