Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling.

ABSTRACT: The transcription factor E74-like factor 5 (Elf5) functions downstream of the prolactin receptor signaling pathway and plays an important role in mammary gland development. Using conditional mouse knockouts, we have previously shown that Elf5-null mammary glands exhibit a complete failure of alveologenesis during pregnancy. The Elf5-null developmental phenotype is mediated through alteration in the expression of several critical genes involved in alveologenesis, particularly those belonging to the JAK/STAT pathway. Here, we demonstrate that in addition to regulating terminal differentiation of alveolar cells, Elf5 also plays a critical role in determining cell fate and in regulating the stem/progenitor function of the mammary epithelium. Targeted deletion of Elf5 in the mammary glands lead

SUBMITTER: Chakrabarti R 

PROVIDER: S-EPMC5606133 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature