Dataset Information

Use of antiretrovirals in HIV-infected children in a tuberculosis prevention trial: IMPAACT P1041.

ABSTRACT:

Setting

International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1041, a tuberculosis (TB) prevention trial conducted among children enrolled from 2004 to 2008 during South Africa's roll-out of combination antiretroviral therapy (ART).

Objective

To estimate TB incidence and mortality and the effect of ART.

Design

Children were pre-screened to exclude TB disease and exposure, actively screened 3-monthly for TB exposure and symptoms, and provided post-exposure isoniazid prophylaxis therapy (IPT). TB diagnoses were definite, probable, or possible, and mortality all-cause. Testing was at the 5% significance level.