Weathering the storm: Improving therapeutic interventions for cytokine storm syndromes by targeting disease pathogenesis.

ABSTRACT: Cytokine storm syndromes require rapid diagnosis and treatment to limit the morbidity and mortality caused by the hyperinflammatory state that characterizes these devastating conditions. Herein, we discuss the current knowledge that guides our therapeutic decision-making and personalization of treatment for patients with cytokine storm syndromes. Firstly, ICU-level supportive care is often required to stabilize patients with fulminant disease while additional diagnostic evaluations proceed to determine the underlying cause of cytokine storm. Pharmacologic interventions should be focused on removing the inciting trigger of inflammation and initiation of an individualized immunosuppressive regimen when immune activation is central to the underlying disease pathophysiology. Monitoring for a c

SUBMITTER: Weaver LK 

PROVIDER: S-EPMC5606329 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature