Systems biology of oxygen homeostasis.

ABSTRACT: Metazoan species maintain oxygen homeostasis through the activity of hypoxia-inducible factors, which are transcriptional activators that regulate the expression of hundreds of genes to match O₂ supply and demand. Here, we review the involvement of hypoxia-inducible factors in the molecular physiology and pathophysiology of cellular O₂ sensing, O₂ delivery, O₂ utilization, and systemic O₂ sensing. WIREs Syst Biol Med 2017, 9:e1382. doi: 10.1002/wsbm.1382 For further resources related to this article, please visit the WIREs website.

SUBMITTER: Samanta D 

PROVIDER: S-EPMC5606335 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature