Comparative safety and efficacy of vasopressors for mortality in septic shock: A network meta-analysis.

ABSTRACT:

Introduction

Septic shock is a life-threatening condition requiring vasopressor agents to support the circulatory system. Several agents exist with choice typically guided by the specific clinical scenario. We used a network meta-analysis approach to rate the comparative efficacy and safety of vasopressors for mortality and arrhythmia incidence in septic shock patients.

Methods

We performed a comprehensive electronic database search including Medline, Embase, Science Citation Index Expanded and the Cochrane database. Randomised trials investigating vasopressor agents in septic shock patients and specifically assessing 28-day mortality or arrhythmia incidence were included. A Bayesian network meta-analysis was performed using Markov chain Monte Carlo methods.

Results

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SUBMITTER: Nagendran M 

PROVIDER: S-EPMC5606402 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature