Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection Strategies.

ABSTRACT: Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat solid organ malignancies. However, serious side effects have been associated with its use, such as bilateral, progressive, irreversible, dose-dependent neurosensory hearing loss. Current evidence indicates that cisplatin triggers the production of reactive oxygen species in target tissues in the inner ear. A variety of agents that protect against cisplatin-induced ototoxicity have been successfully tested in cell culture and animal models. However, many of them interfere with the therapeutic effect of cisplatin, and therefore are not suitable for systemic administration in clinical practice. Consequently, local administration strategies, namely intratympanic administration, have been developed to achieve ot

SUBMITTER: Callejo A 

PROVIDER: S-EPMC5606684 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature