The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea.

ABSTRACT: The molecular force of blood-stage infection (_molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between _molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-_molFOB = 0-18, Pv-_molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-_molFOB increased >3 fold (relati

SUBMITTER: Hofmann NE 

PROVIDER: S-EPMC5606846 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature