Sleep architecture and the risk of incident dementia in the community.

ABSTRACT:

Objective

Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. We examined the associations between sleep architecture and the prospective risk of incident dementia in the community-based Framingham Heart Study (FHS).

Methods

Our sample comprised a subset of 321 FHS Offspring participants who participated in the Sleep Heart Health Study between 1995 and 1998 and who were aged over 60 years at the time of sleep assessment (mean age 67 ± 5 years, 50% male). Stages of sleep were quantified using home-based polysomnography. Participants were followed for a maximum of 19 years for incident dementia (mean follow-up 12 ± 5 years).

Results

We observed 32 cases of incident dementia; 24 were consistent

SUBMITTER: Pase MP 

PROVIDER: S-EPMC5606917 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature