Non-alcoholic Fatty Liver Disease in Lean Subjects: Characteristics and Implications.

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is commonly diagnosed in obese subjects; however, it is not rare among lean individuals. Given the absence of traditional risk factors, it tends to remain under-recognised. The metabolic profiles of lean NAFLD patients are frequently comparable to those of obese NAFLD patients. Though results from several studies have been mixed, it has been generally revealed that lean subjects with NAFLD have minor insulin resistance compared to that in obese NAFLD. Several genetic variants are associated with NAFLD without insulin resistance. Some data suggest that the prevalence of steatohepatitis and advanced fibrosis do not differ significantly between lean and obese NAFLD; however, the former tend to have less severe disease at presentation. The underlying p

SUBMITTER: Kumar R 

PROVIDER: S-EPMC5606968 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature