Chemotherapy for Hepatocellular Carcinoma: Current Evidence and Future Perspectives.

ABSTRACT: Hepatocarcinogenesis is a multistep process, heralded by abnormalities in cell differentiation and proliferation and sustained by an aberrant neoangiogenesis. Understanding the underlying molecular pathogenesis leading to hepatocellular carcinoma is a prerequisite to develop new drugs that will hamper or block the steps of these pathways. As hepatocellular carcinoma has higher arterial vascularization than normal liver, this could be a good target for novel molecular therapies. Introduction of the antiangiogenic drug sorafenib into clinical practice since 2008 has led to new perspectives in the management of this tumor. The importance of this drug lies not only in the modest gain of patients' survival, but in having opened a roadmap towards the development of new molecules and targets. Unf

SUBMITTER: Rinninella E 

PROVIDER: S-EPMC5606970 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature