Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis.

ABSTRACT: Cross-ethnic genetic studies can leverage power from differences in disease epidemiology and population-specific genetic architecture. In particular, the differences in linkage disequilibrium and allele frequency patterns across ethnic groups may increase gene-mapping resolution. Here we use cross-ethnic genetic data in sporadic amyotrophic lateral sclerosis (ALS), an adult-onset, rapidly progressing neurodegenerative disease. We report analyses of novel genome-wide association study data of 1,234 ALS cases and 2,850 controls. We find a significant association of rs10463311 spanning GPX3-TNIP1 with ALS (p = 1.3 × 10^-8), with replication support from two independent Australian samples (combined 576 cases and 683 controls, p = 1.7 × 10^-3). Both GPX3 and TNIP1 interact w

SUBMITTER: Benyamin B 

PROVIDER: S-EPMC5606989 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature