Network organization is globally atypical in autism: A graph theory study of intrinsic functional connectivity.

ABSTRACT:

Background

Despite abundant evidence of brain network anomalies in autism spectrum disorder (ASD), findings have varied from broad functional underconnectivity to broad overconnectivity. Rather than pursuing overly simplifying general hypotheses ('under' vs. 'over'), we tested the hypothesis of atypical network distribution in ASD (i.e., participation of unusual loci in distributed functional networks).

Methods

We used a selective high-quality data subset from the ABIDE datashare (including 111 ASD and 174 typically developing [TD] participants) and several graph theory metrics. Resting state functional MRI data were preprocessed and analyzed for detection of low-frequency intrinsic signal correlations. Groups were tightly matched for available demographics and head m

SUBMITTER: Keown CL 

PROVIDER: S-EPMC5607014 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature