Association of Elevated Reward Prediction Error Response With Weight Gain in Adolescent Anorexia Nervosa.

ABSTRACT:

Objective

Anorexia nervosa is a psychiatric disorder of unknown etiology. Understanding associations between behavior and neurobiology is important in treatment development. Using a novel monetary reward task during functional magnetic resonance brain imaging, the authors tested how brain reward learning in adolescent anorexia nervosa changes with weight restoration.

Method

Female adolescents with anorexia nervosa (N=21; mean age, 16.4 years [SD=1.9]) underwent functional MRI (fMRI) before and after treatment; similarly, healthy female control adolescents (N=21; mean age, 15.2 years [SD=2.4]) underwent fMRI on two occasions. Brain function was tested using the reward prediction error construct, a computational model for reward receipt and omission related to motivation and n

SUBMITTER: DeGuzman M 

PROVIDER: S-EPMC5607032 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature