[¹⁸F]Fluoromisonidazole PET in rectal cancer.

ABSTRACT:

Background

There is an increasing interest in developing predictive biomarkers of tissue hypoxia using functional imaging for personalised radiotherapy in patients with rectal cancer that are considered for neoadjuvant chemoradiotherapy (CRT). The study explores [¹⁸F]fluoromisonidazole ([¹⁸F]FMISO) positron emission tomography (PET) scans for predicting clinical response in rectal cancer patients receiving neoadjuvant CRT.

Methods

Patients with biopsy-proven rectal adenocarcinoma were imaged at 0-45 min, 2 and 4 h, at baseline and after 8-10 fractions of CRT (week 2). The first 6 patients did not receive an enema (the non-enema group) and the last 4 patients received an enema before PET-CT scan (the enema group). [¹⁸F]FMISO production failed

SUBMITTER: Puri T 

PROVIDER: S-EPMC5607050 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature