Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study.

ABSTRACT:

Objective

A history of periodontal disease and the presence of circulating antibodies to selected oral pathogens have been associated with increased risk of pancreatic cancer; however, direct relationships of oral microbes with pancreatic cancer have not been evaluated in prospective studies. We examine the relationship of oral microbiota with subsequent risk of pancreatic cancer in a large nested case-control study.

Design

We selected 361 incident adenocarcinoma of pancreas and 371 matched controls from two prospective cohort studies, the American Cancer Society Cancer Prevention Study II and the National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. From pre-diagnostic oral wash samples, we characterised the composition of the oral microbi

SUBMITTER: Fan X 

PROVIDER: S-EPMC5607064 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature