Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates.

ABSTRACT:

Objective

Atherosclerosis developed during premenopausal years predicts postmenopausal atherosclerosis burden. Selective serotonin reuptake inhibitor (SSRI) antidepressants, recently approved for hot flushes, have been associated with increased ischemic stroke risk in several observational studies; however, effects on carotid artery atherosclerosis, a strong predictor of future vascular events, are unknown.

Methods

The effects of chronic administration of a commonly prescribed SSRI, sertraline HCl, on atherosclerosis in the carotid artery was assessed in a placebo-controlled, longitudinal, randomized study of premeonopausal depressed and nondepressed cynomolgus monkeys (Macaca fascicularis; n = 42). Physiologic and behavioral phenotypes were evaluated at baseline and after 1

SUBMITTER: Silverstein-Metzler MG 

PROVIDER: S-EPMC5607066 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature