A Population-Based Study of Effects of Genetic Loci on Orofacial Clefts.

ABSTRACT: Prior genome-wide association studies for oral clefts have focused on clinic-based samples with unclear generalizability. Prior samples were also small for investigating effects by cleft type and exclusively studied isolated clefts (those occurring without other birth defects). We estimated the effects of 17 top loci on cleft types in both isolated and nonisolated cases in the largest consortium to date of European-descent population-based studies. Our analytic approach focused on a mother-child dyad case-control design, but it also allowed analyzing mother-only or child-only genotypes to maximize power. Our total sample included 1,875 cases with isolated clefts, 459 cases with nonisolated clefts, and 3,749 controls. After correcting for multiple testing, we observed significant associatio

SUBMITTER: Moreno Uribe LM 

PROVIDER: S-EPMC5607104 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature