The genome-wide associated candidate gene ZNF804A and psychosis-proneness: Evidence of sex-modulated association.

ABSTRACT:

Background

The Zinc finger protein 804A (ZNF804A) is a promising candidate gene for schizophrenia and the broader psychosis phenotype that emerged from genome-wide association studies. It is related to neurodevelopment and associated to severe symptoms of schizophrenia and alterations in brain structure, as well as positive schizotypal personality traits in non-clinical samples. Moreover, a female-specific association has been observed between ZNF804A and schizophrenia.

Aim

The present study examined the association of two ZNF804A polymorphisms (rs1344706 and rs7597593) with the positive dimension of schizotypy and psychotic-like experiences in a sample of 808 non-clinical subjects. Additionally, we wanted to explore whether the sexual differences reported in schizophrenia a

SUBMITTER: de Castro-Catala M 

PROVIDER: S-EPMC5607189 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature