Re-evaluation of the interrelationships among the behavioral tests in rats exposed to chronic unpredictable mild stress.

ABSTRACT: The chronic unpredictable mild stress model of depression has been widely used as an experimental tool to investigate human psychopathology. Our objective was to provide an update on the validity and reliability of the chronic unpredictable mild stress model, by analyzing the interrelationships among the indexes using stepwise discriminant analysis and Pearson correlation coefficient to examine the possible combinations. We evaluated the depressive rats in both the presence and the absence of chronic unpredictable mild stress, using weight change, percentage of sucrose preference, coat state, splash test, open-field test, elevated plus-maze test, forced swimming test, and Morris water maze test. The results showed that 6-week-long chronic unpredictable mild stress produces significant depr

SUBMITTER: Hu C 

PROVIDER: S-EPMC5607203 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature