Blood-based metabolic signatures in Alzheimer's disease.

ABSTRACT:

Introduction

Identification of blood-based metabolic changes might provide early and easy-to-obtain biomarkers.

Methods

We included 127 Alzheimer's disease (AD) patients and 121 control subjects with cerebrospinal fluid biomarker-confirmed diagnosis (cutoff tau/amyloid β peptide 42: 0.52). Mass spectrometry platforms determined the concentrations of 53 amine compounds, 22 organic acid compounds, 120 lipid compounds, and 40 oxidative stress compounds. Multiple signatures were assessed: differential expression (nested linear models), classification (logistic regression), and regulatory (network extraction).

Results

Twenty-six metabolites were differentially expressed. Metabolites improved the classification performance of clinical variables from 74% to 79%. Network mode

SUBMITTER: de Leeuw FA 

PROVIDER: S-EPMC5607205 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature