Drug release from core-shell PVA/silk fibroin nanoparticles fabricated by one-step electrospraying.

ABSTRACT: Silk fibroin (SF), a FDA-approved natural protein, is renowned for its great biocompatibility, biodegradability, and mechanical properties. SF-based nanoparticles provide new options for drug delivery with their tunable drug loading and release properties. To take advantage of the features of carrier polymers, we present a one-step electrospraying method that combines SF, polyvinyl alcohol (PVA) and therapeutic drugs without an emulsion process. A distinct core-shell structure was obtained with the PVA core and silk shell after the system was properly set up. The model drug, doxorubicin, was encapsulated in the core with a greater than 90% drug encapsulation efficiency. Controllable drug release profiles were achieved by alternating the PVA/SF ratio. Although the initial burst release of t

SUBMITTER: Cao Y 

PROVIDER: S-EPMC5607240 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature