Th17-Mediated Cross Protection against Pneumococcal Carriage by Vaccination with a Variable Antigen.

ABSTRACT: Serotype-specific protection against Streptococcus pneumoniae is an important limitation of the current polysaccharide-based vaccines. To prevent serotype replacement, reduce transmission, and limit the emergence of new variants, it is essential to induce broad protection and restrict pneumococcal colonization. In this study, we used a prototype vaccine formulation consisting of lipopolysaccharide (LPS)-detoxified outer membrane vesicles (OMVs) from Salmonella enterica serovar Typhimurium displaying the variable N terminus of PspA (α1α2) for intranasal vaccination, which induced strong Th17 immunity associated with a substantial reduction of pneumococcal colonization. Despite the variable nature of this protein, a common major histocompatibility complex class (MHC-II) epitope was identifie

SUBMITTER: Kuipers K 

PROVIDER: S-EPMC5607416 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature