Iterative analysis of cerebrovascular reactivity dynamic response by temporal decomposition.

ABSTRACT:

Objective

To improve quantitative cerebrovascular reactivity (CVR) measurements and CO ₂ arrival times, we present an iterative analysis capable of decomposing different temporal components of the dynamic carbon dioxide- Blood Oxygen-Level Dependent (CO ₂-BOLD) relationship.

Experimental design

Decomposition of the dynamic parameters included a redefinition of the voxel-wise CO ₂ arrival time, and a separation from the vascular response to a stepwise increase in CO ₂ (Delay to signal Plateau - DTP) and a decrease in CO ₂ (Delay to signal Baseline -DTB). Twenty-five (normal) datasets, obtained from BOLD MRI combined with a standardized pseudo-square wave CO ₂ change, were co-registered to generate reference atl

SUBMITTER: van Niftrik CHB 

PROVIDER: S-EPMC5607533 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature