Genetic alterations of IDH1 and Vegf in brain tumors.

ABSTRACT:

Background

This study evaluates the presence of R132H mutation in isocitrate dehydrogenase (IDH1) gene and the vascular endothelial growth factor (VEGF) +936 C/T polymorphism in brain tumors. The impact of these genetic alterations on overall survival (OS) and progression free survival (PFS) was evaluated.

Methods

A cohort of 80 patients surgically treated at Hospital Clínico San Carlos, Madrid, between March 2004 and November 2012, was analyzed. Tumors were distributed in 73 primary brain tumors (gliomas, meningiomas, hemangiopericytomas and hemangioblastomas) and seven secondary tumors evolved from a low grade glioma, thus providing a mixed sample.

Results

IDH1^R132H gene mutation was found in 12 patients (15%) and appears more

SUBMITTER: Veganzones S 

PROVIDER: S-EPMC5607534 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature