Detection and application of neurochemical profile by multiple regional ¹H-MRS in Parkinson's disease.

ABSTRACT:

Introduction

The accurate diagnosis and monitoring of idiopathic Parkinson disease (PD), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify a neurochemical profile in multiple regions of the PD brain and healthy controls by proton magnetic resonance spectroscopy (¹H-MRS). We aimed to track changes of the brain neurochemical, quantify neuronal loss, and further determine the diagnostic value of ¹H-MRS.

Methods

PD patients and healthy controls recruited from Second Affiliated Hospital of Shantou University Medical College, Shantou, southern China, underwent ¹H-MRS. Chemical information was obtained for ratios of N-acetylaspartate to creatine (NAA/Cr), NAA to choline (NAA/Cho), and Cho to Cr for

SUBMITTER: Guan J 

PROVIDER: S-EPMC5607555 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature