Adult newborn neurons interfere with fear discrimination in a protocol-dependent manner.

ABSTRACT:

Introduction

Significant enhancement of neurogenesis is known to occur in response to a variety of brain insults such as traumatic brain injury. Previous studies have demonstrated that injury-induced newborn neurons are required for hippocampus-dependent spatial learning and memory tasks like the Morris water maze, but not in contextual fear conditioning that requires both the hippocampus and amygdala. Recently, the dentate gyrus, where adult hippocampal neurogenesis occurs, has been implicated in processing information to form specific memory under specific environmental stimuli in a process known as pattern separation.

Methods

To test whether injury-induced newborn neurons facilitate pattern separation, hippocampus-dependent contextual fear discrimination was performed usi

SUBMITTER: Yu TS 

PROVIDER: S-EPMC5607558 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature